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Issue 33, 2019
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Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors

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Abstract

Nanoparticle receptors were synthesized through micellar imprinting to bind glycosphingolipids with 20–140 μM binding affinities, meanwhile distinguishing glycan composition, the number of acyl chains, and hydroxylation of acyl chains in the lipids. The strong binding enabled the receptors to protect their target glycolipids dispersed in lipid membranes from enzymatic degradation.

Graphical abstract: Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors

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Publication details

The article was received on 28 Feb 2019, accepted on 28 Mar 2019 and first published on 28 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01694E
Chem. Commun., 2019,55, 4773-4776

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    Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors

    R. W. Gunasekara and Y. Zhao, Chem. Commun., 2019, 55, 4773
    DOI: 10.1039/C9CC01694E

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