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Issue 30, 2019
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Magnesium-mediated arylation of amines via C–F bond activation of fluoroarenes

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Abstract

A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C–F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C–N bonds via nucleophilic substitution.

Graphical abstract: Magnesium-mediated arylation of amines via C–F bond activation of fluoroarenes

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Publication details

The article was received on 27 Feb 2019, accepted on 12 Mar 2019 and first published on 13 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01670H
Chem. Commun., 2019,55, 4339-4342

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    Magnesium-mediated arylation of amines via C–F bond activation of fluoroarenes

    L. J. Bole, L. Davin, A. R. Kennedy, R. McLellan and E. Hevia, Chem. Commun., 2019, 55, 4339
    DOI: 10.1039/C9CC01670H

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