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Issue 29, 2019
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A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum

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Abstract

A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed. Based on ultrafiltration of a human serum-nanoparticle mixture and the mass spectrometric analysis of filtrates, this assay revealed for iron oxide nanoparticles coated with poly(acrylic acid) satisfactory biopersistence and a bimodal binding to sulfur-containing biomolecules, with the formation of the protein corona completed in about 1 h.

Graphical abstract: A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum

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Publication details

The article was received on 28 Feb 2019, accepted on 18 Mar 2019 and first published on 18 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01642B
Chem. Commun., 2019,55, 4270-4272

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    A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum

    O. V. Kuznetsova, I. S. Reshetnikova, S. N. Shtykov, V. K. Karandashev, B. K. Keppler and A. R. Timerbaev, Chem. Commun., 2019, 55, 4270
    DOI: 10.1039/C9CC01642B

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