Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy

Abstract

A multifunctional photosensitive and photothermal nanomedicine, AMP–Ce6–HA, was prepared by sequentially layering hard and soft functional molecules. AMP–Ce6–HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen-enhanced photodynamic combination therapy was much more effective than the single one.