Jump to main content
Jump to site search

Issue 27, 2019
Previous Article Next Article

A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

Author affiliations

Abstract

A fluorescence turn-on probe for amyloid detection in the extreme near-infrared region (>750 nm) is a highly desirable technological evolution from the view point of potential in vivo applications. Herein, we report a molecular rotor-based amyloid sensor probe which, on binding to the insulin amyloid fibril, registers a large turn-on emission in the near-infrared region, and records an exceptionally large red-shifted emission wavelength of ∼770 nm along with a Stokes’ shift of ∼150 nm, the highest reported to date for any amyloid sensor probe, in the insulin fibril bound form, in the near-infrared region. Importantly, when bound to insulin fibrils, this probe also exhibits an exceptionally large red-shift of ∼120 nm in the absorption spectra, which enables the naked eye in vitro detection of amyloid fibrils.

Graphical abstract: A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

Back to tab navigation

Supplementary files

Article information


Submitted
15 Feb 2019
Accepted
04 Mar 2019
First published
05 Mar 2019

Chem. Commun., 2019,55, 3907-3910
Article type
Communication

A molecular rotor-based turn-on sensor probe for amyloid fibrils in the extreme near-infrared region

N. H. Mudliar and P. K. Singh, Chem. Commun., 2019, 55, 3907
DOI: 10.1039/C9CC01262A

Social activity

Search articles by author

Spotlight

Advertisements