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Issue 42, 2019

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase

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Abstract

Through the use of time-resolved pH-jump spectroscopy, we demonstrate how proton transfer is coupled to inter-copper electron transfer in a copper nitrite reductase (CuNiR). Combined use of electron paramagnetic resonance spectroscopy with solvent viscosity- and pressure-dependence pH-jump stopped-flow spectroscopy is used to show that solvent-slaved protein motions are linked to this proton coupled electron transfer step in CuNiR.

Graphical abstract: Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase

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Article information


Submitted
04 Feb 2019
Accepted
07 Mar 2019
First published
03 May 2019

This article is Open Access

Chem. Commun., 2019,55, 5863-5866
Article type
Communication

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase

T. M. Hedison, D. J. Heyes, M. Shanmugam, A. I. Iorgu and N. S. Scrutton, Chem. Commun., 2019, 55, 5863 DOI: 10.1039/C9CC01026B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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