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Issue 42, 2019
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Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-β

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Abstract

We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)-bound amyloid-β [Zn(II)–Aβ], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)–Aβ (phen, 1, and 2), or both (3).

Graphical abstract: Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)–amyloid-β

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Publication details

The article was received on 03 Feb 2019, accepted on 23 Apr 2019 and first published on 23 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC01005J
Chem. Commun., 2019,55, 5847-5850

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    Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)–amyloid-β

    Y. Yi, J. Han, M. H. Park, N. Park, E. Nam, H. K. Jin, J. Bae and M. H. Lim, Chem. Commun., 2019, 55, 5847
    DOI: 10.1039/C9CC01005J

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