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Issue 22, 2019
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Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

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Abstract

In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.

Graphical abstract: Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

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Supplementary files

Article information


Submitted
19 Jan 2019
Accepted
06 Feb 2019
First published
19 Feb 2019

Chem. Commun., 2019,55, 3278-3281
Article type
Communication

Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

Y. Wan, Y. Zhou, K. Xiao, C. Nie, J. Zhang, C. Liu, T. Chen and X. Chu, Chem. Commun., 2019, 55, 3278
DOI: 10.1039/C9CC00451C

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