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Issue 29, 2019
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Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

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Abstract

Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18F and 64Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized with acceptable radiochemical characteristics and their in vivo pharmacokinetics and PD-L1 imaging capability were systematically evaluated. This proof-of-principle study may provide new possibilities for PD-L1 PET imaging in cancers.

Graphical abstract: Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

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Submitted
18 Jan 2019
Accepted
20 Feb 2019
First published
21 Feb 2019

Chem. Commun., 2019,55, 4162-4165
Article type
Communication

Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

H. Kuan, H. Masayuki, L. Xie, Y. Zhang, N. Kotaro, S. Hisashi and M. Zhang, Chem. Commun., 2019, 55, 4162
DOI: 10.1039/C9CC00445A

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