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Issue 29, 2019
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Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

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Abstract

Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18F and 64Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized with acceptable radiochemical characteristics and their in vivo pharmacokinetics and PD-L1 imaging capability were systematically evaluated. This proof-of-principle study may provide new possibilities for PD-L1 PET imaging in cancers.

Graphical abstract: Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

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Publication details

The article was received on 18 Jan 2019, accepted on 20 Feb 2019 and first published on 21 Feb 2019


Article type: Communication
DOI: 10.1039/C9CC00445A
Chem. Commun., 2019,55, 4162-4165

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    Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

    H. Kuan, H. Masayuki, L. Xie, Y. Zhang, N. Kotaro, S. Hisashi and M. Zhang, Chem. Commun., 2019, 55, 4162
    DOI: 10.1039/C9CC00445A

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