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Issue 27, 2019
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Reductive N-methylation of quinolines with paraformaldehyde and H2 for sustainable synthesis of N-methyl tetrahydroquinolines

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Abstract

A new and straightforward method was developed for the synthesis of N-methyl-1,2,3,4-tetrahydroquinolines by one-pot reductive N-methylation of quinolines with paraformaldehyde and H2 over Pd/C catalyst. A series of functional MTHQs, including (±)-galipinine and (±)-angustrureine were successfully synthesized in good to excellent yields by applying this simple catalyst system.

Graphical abstract: Reductive N-methylation of quinolines with paraformaldehyde and H2 for sustainable synthesis of N-methyl tetrahydroquinolines

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Article information


Submitted
31 Dec 2018
Accepted
08 Mar 2019
First published
08 Mar 2019

Chem. Commun., 2019,55, 3915-3918
Article type
Communication

Reductive N-methylation of quinolines with paraformaldehyde and H2 for sustainable synthesis of N-methyl tetrahydroquinolines

H. Wang, Y. Huang, Q. Jiang, X. Dai and F. Shi, Chem. Commun., 2019, 55, 3915
DOI: 10.1039/C8CC10309G

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