Issue 25, 2019
From the journal:

Chemical Communications

Hydrated ionic liquids enable both solubilisation and refolding of aggregated concanavalin A†

Kyoko Fujita, ORCID logo *a   Roka Nakano,b   Risa Nakaba,a   Nobuhumi Nakamura ORCID logo b  and  Hiroyuki Ohno ORCID logo b  

* Corresponding authors

a Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, Japan
E-mail: kyokof@toyaku.ac.jp

b Department of Biotechnology and Functional Ionic Liquid laboratories, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan

Abstract

The dissolution and refolding of aggregated concanavalin A have been achieved, in hydrated ionic liquids containing a limited number of water molecules. Both ammonium and phosphonium salts were examined to find a suitable hydrophobicity of ions and water content for refolding. Recovery of sugar recognition was confirmed as a proof of refolding.

Graphical abstract: Hydrated ionic liquids enable both solubilisation and refolding of aggregated concanavalin A

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC10102G
Article type
Communication
Submitted
21 Dec 2018
Accepted
05 Feb 2019
First published
06 Feb 2019

Chem. Commun., 2019,55, 3578-3581

Permissions

Request permissions

Hydrated ionic liquids enable both solubilisation and refolding of aggregated concanavalin A

K. Fujita, R. Nakano, R. Nakaba, N. Nakamura and H. Ohno, Chem. Commun., 2019, 55, 3578 DOI: 10.1039/C8CC10102G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements