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Issue 31, 2019
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DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

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Abstract

We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA.

Graphical abstract: DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

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Publication details

The article was received on 20 Dec 2018, accepted on 14 Feb 2019 and first published on 11 Mar 2019


Article type: Communication
DOI: 10.1039/C8CC10091H
Chem. Commun., 2019,55, 4467-4470
  • Open access: Creative Commons BY-NC license
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    DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

    J. Gao, A. K. Byrd, B. L. Zybailov, J. C. Marecki, M. J. Guderyon, A. D. Edwards, S. Chib, K. L. West, Z. J. Waldrip, S. G. Mackintosh, Z. Gao, A. A. Putnam, E. Jankowsky and K. D. Raney, Chem. Commun., 2019, 55, 4467
    DOI: 10.1039/C8CC10091H

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