Coordination microparticle vaccines engineered from tumor cell templates

Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(III) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.