Issue 21, 2019

A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

Abstract

Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a β-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(II) centers acted as the PDT active sites, and the biocompatible polysaccharide β-cyclodextrins acted as the non-covalent linkers. Significantly, the resultant Ru/polysaccharide/protein exhibited not only specific targeting properties towards tumor cells but also high PDT ability under the irradiation of visible light. Furthermore, the assembly showed selective killing towards tumor cells along with negligible toxicity towards normal cells.

Graphical abstract: A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

Supplementary files

Article information

Article type
Communication
Submitted
17 Dec 2018
Accepted
14 Feb 2019
First published
15 Feb 2019

Chem. Commun., 2019,55, 3148-3151

A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability

H. Fu, Y. Chen, Q. Yu and Y. Liu, Chem. Commun., 2019, 55, 3148 DOI: 10.1039/C8CC09964B

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