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Issue 15, 2019
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“Top” or “bottom” switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate

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Abstract

Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).

Graphical abstract: “Top” or “bottom” switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate

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Publication details

The article was received on 16 Dec 2018, accepted on 25 Jan 2019 and first published on 25 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09951K
Citation: Chem. Commun., 2019,55, 2198-2201

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    “Top” or “bottom” switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate

    Y. Hu, J. Wang, Y. Cen, H. Zheng, M. Huang, X. Lin and Q. Wu, Chem. Commun., 2019, 55, 2198
    DOI: 10.1039/C8CC09951K

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