Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2019
Previous Article Next Article

Ligand-controlled iridium-catalyzed semihydrogenation of alkynes with ethanol: highly stereoselective synthesis of E- and Z-alkenes

Author affiliations

Abstract

A ligand-controlled iridium-catalyzed semihydrogenation of alkynes to E- and Z-alkenes with ethanol was developed. Effective selectivity control was achieved by ligand regulation. The use of 1,2-bis(diphenylphosphino)ethane (DPPE) and 1,5-cyclooctadiene (COD) was critical for the stereoselective semihydrogenation of alkynes. The general applicability of this procedure was highlighted by the synthesis of more than 40 alkenes, with good stereoselectivities. The value of our approach in practical applications was investigated by studying the effects of pinosylvin and 4,4′-dihydroxystilbene (DHS) on zebrafish as a vertebrate model.

Graphical abstract: Ligand-controlled iridium-catalyzed semihydrogenation of alkynes with ethanol: highly stereoselective synthesis of E- and Z-alkenes

Back to tab navigation

Supplementary files

Article information


Submitted
07 Dec 2018
Accepted
18 Jan 2019
First published
24 Jan 2019

Chem. Commun., 2019,55, 1903-1906
Article type
Communication

Ligand-controlled iridium-catalyzed semihydrogenation of alkynes with ethanol: highly stereoselective synthesis of E- and Z-alkenes

J. Yang, C. Wang, Y. Sun, X. Man, J. Li and F. Sun, Chem. Commun., 2019, 55, 1903
DOI: 10.1039/C8CC09714C

Social activity

Search articles by author

Spotlight

Advertisements