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Issue 21, 2019
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Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

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Abstract

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

Graphical abstract: Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

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Article information


Submitted
05 Dec 2018
Accepted
18 Feb 2019
First published
19 Feb 2019

Chem. Commun., 2019,55, 3124-3127
Article type
Communication

Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

B. van der Wildt, B. Shen and F. T. Chin, Chem. Commun., 2019, 55, 3124
DOI: 10.1039/C8CC09661A

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