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Issue 15, 2019
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Site-specific incorporation of multiple units of functional nucleotides into DNA using a step-wise approach with polymerase and its application to monitoring DNA structural changes

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Abstract

We have developed a new method, a step-wise approach with polymerase, for site-specific incorporation of multiple units of functional nucleotides into DNA to form hairpin secondary structures. The fluorescence of the resulting DNA incorporating the functional nucleotides varied upon transitioning from single-strand to hairpin and duplex structures.

Graphical abstract: Site-specific incorporation of multiple units of functional nucleotides into DNA using a step-wise approach with polymerase and its application to monitoring DNA structural changes

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Article information


Submitted
28 Nov 2018
Accepted
16 Jan 2019
First published
17 Jan 2019

Chem. Commun., 2019,55, 2158-2161
Article type
Communication

Site-specific incorporation of multiple units of functional nucleotides into DNA using a step-wise approach with polymerase and its application to monitoring DNA structural changes

B. Huy Le, V. T. Nguyen and Y. J. Seo, Chem. Commun., 2019, 55, 2158
DOI: 10.1039/C8CC09444F

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