Issue 8, 2019
From the journal:

Chemical Communications

Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum†

Xue-Mei Hou,‡ab   Ting-Mei Liang,‡ab   Zhi-Yong Guo,c   Chang-Yun Wang ORCID logo ab  and  Chang-Lun Shao ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China
E-mail: shaochanglun@163.com

b Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, People's Republic of China

c Hubei Key Laboratory of Natural Product Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, People's Republic of China

Abstract

Integrating molecular networking and 1H NMR techniques successfully enabled the discovery of three new cycloheptapeptides, asperversiamides A–C (1–3). Their complete structures were further confirmed by total synthesis. All three compounds exhibited potent inhibitory activity against Mycobacterium marinum.

Graphical abstract: Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum

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Article information

DOI
https://doi.org/10.1039/C8CC09347D
Article type
Communication
Submitted
24 Nov 2018
Accepted
27 Dec 2018
First published
28 Dec 2018

Chem. Commun., 2019,55, 1104-1107

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Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum

X. Hou, T. Liang, Z. Guo, C. Wang and C. Shao, Chem. Commun., 2019, 55, 1104 DOI: 10.1039/C8CC09347D

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