Issue 1, 2019

Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

Abstract

Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been realized for the first time. As an application of this methodology, a concise synthesis of the clinical drug tiletamine was also achieved via a three-step procedure from 2-nitrocyclohexanone without the isolation of intermediates.

Graphical abstract: Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

Supplementary files

Article information

Article type
Communication
Submitted
09 Nov 2018
Accepted
27 Nov 2018
First published
28 Nov 2018

Chem. Commun., 2019,55, 119-122

Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

Y. An, X. Zhang, Z. Li, W. Xiong, R. Yu and F. Zhang, Chem. Commun., 2019, 55, 119 DOI: 10.1039/C8CC08920E

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