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Issue 6, 2019
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Engineering bioorthogonal protein–polymer hybrid hydrogel as a functional protein immobilization platform

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Abstract

We demonstrate the synthesis of protein–polymer hybrid hydrogel that can be used as a platform for immobilizing functional proteins. Orthogonal chemistry was employed for cross-linking the hybrid network and conjugating proteins to the gel backbone, allowing for the convenient, one-pot formation of a functionalized hydrogel. The resulting hydrogel had tunable mechanical properties, was stable in solution, and biocompatible.

Graphical abstract: Engineering bioorthogonal protein–polymer hybrid hydrogel as a functional protein immobilization platform

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Publication details

The article was received on 01 Nov 2018, accepted on 11 Dec 2018 and first published on 12 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08720B
Citation: Chem. Commun., 2019,55, 806-809

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    Engineering bioorthogonal protein–polymer hybrid hydrogel as a functional protein immobilization platform

    S. Lim, G. A. Jung, R. J. Muckom, D. J. Glover and D. S. Clark, Chem. Commun., 2019, 55, 806
    DOI: 10.1039/C8CC08720B

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