Jump to main content
Jump to site search

Issue 2, 2019
Previous Article Next Article

Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction

Author affiliations

Abstract

An unprecedented strategy of a rhodium-catalysed redox-neutral cascade reaction starting from benzamides and cyclopropenones via addition of a C–H bond into a polar carbonyl group for the rapid assembly of cyclopentene spiroisoindolinones has been developed. Water was produced as the sole by-product. Metal migration and abstraction of a H-atom from the arylcyclopropenone's aromatic ring are the key steps in building the spirocycle. Two C–C bonds, one C–N bond and an N-substituted quaternary carbon center were formed sequentially in a one pot manner.

Graphical abstract: Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction

Back to tab navigation

Supplementary files

Article information


Submitted
09 Oct 2018
Accepted
26 Oct 2018
First published
30 Oct 2018

Chem. Commun., 2019,55, 163-166
Article type
Communication

Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction

T. Yuan, C. Pi, C. You, X. Cui, S. Du, T. Wan and Y. Wu, Chem. Commun., 2019, 55, 163
DOI: 10.1039/C8CC08081J

Social activity

Search articles by author

Spotlight

Advertisements