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Issue 3, 2019
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Manganese catalyzed α-methylation of ketones with methanol as a C1 source

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Abstract

The direct α-methylation of ketones with methanol under hydrogen borrowing conditions using a well-defined manganese PN3P complex as a pre-catalyst was, for the first time, achieved. The reactions typically proceed at 120 °C for 20 h with 3 mol% pre-catalyst loading and in the presence of NaOtBu (50 mol%) as base. The scope of the reaction was extended to the α-methylation of esters.

Graphical abstract: Manganese catalyzed α-methylation of ketones with methanol as a C1 source

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Article information


Submitted
09 Oct 2018
Accepted
30 Nov 2018
First published
10 Dec 2018

Chem. Commun., 2019,55, 314-317
Article type
Communication

Manganese catalyzed α-methylation of ketones with methanol as a C1 source

A. Bruneau-Voisine, L. Pallova, S. Bastin, V. César and J. Sortais, Chem. Commun., 2019, 55, 314
DOI: 10.1039/C8CC08064J

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