Issue 11, 2019
From the journal:

Chemical Communications

A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA†

Duo Lin, ORCID logo a   Tianxun Gong,b   Sufang Qiu,c   Qiong Wu,d   Ching-Yu Tseng,e   Kien Voon Kong,*e   Guannan Chen*d  and  Rong Chen*d  

* Corresponding authors

a College of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China

b State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, China

c Fujian Medical University Cancer Hospital & Fujian Cancer Hospital Radiation Oncology Department, Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, China

d Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, China
E-mail: edado@fjnu.edu.cn, chenr@fjnu.edu.cn

e Department of Chemistry, National Taiwan University, Taipei, Taiwan
E-mail: kvkong@ntu.edu.tw

Abstract

A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform.

Graphical abstract: A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA

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Article information

DOI
https://doi.org/10.1039/C8CC07461E
Article type
Communication
Submitted
14 Sep 2018
Accepted
30 Nov 2018
First published
04 Dec 2018

Chem. Commun., 2019,55, 1548-1551

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A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA

D. Lin, T. Gong, S. Qiu, Q. Wu, C. Tseng, K. V. Kong, G. Chen and R. Chen, Chem. Commun., 2019, 55, 1548 DOI: 10.1039/C8CC07461E

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