Interlayer expansion of 2D MoS2 nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo

Changhui Fu; Longfei Tan; Xiangling Ren; Qiong Wu; Haibo Shao; Jun Ren; Yuxia Zhao; Xianwei Meng

doi:10.1039/C8CC08279K

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Interlayer expansion of 2D MoS₂ nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo†

Changhui Fu,^ad Longfei Tan,^a Xiangling Ren,^a Qiong Wu,^a Haibo Shao,^c Jun Ren,^a Yuxia Zhao

*^b and Xianwei Meng

*^a

Author affiliations

* Corresponding authors

^a Laboratory of Controllable Preparation and Application of Nanomaterials, Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P. R. China
E-mail: mengxw@mail.ipc.ac.cn

^b Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: yuxia.zhao@mail.ipc.ac.cn

^c Department of Radiology, First Hospital of China Medical University, Shenyang 110001, P. R. China

^d University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

Interlayer-expanded MoS₂ (E-MoS₂) nanosheets with an interlayer spacing of 0.94 nm are demonstrated to show an high photothermal conversion efficiency of ∼62%. More importantly, such biocompatible E-MoS₂ nanosheets show highly improved photothermal therapy (PTT) of tumors in vitro and in vivo under near-infrared light irradiation.

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Article information

DOI: https://doi.org/10.1039/C8CC08279K
Article type: Communication
Submitted: 16 Oct 2018
Accepted: 19 Nov 2018
First published: 19 Nov 2018

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Chem. Commun., 2018,54, 13989-13992

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Interlayer expansion of 2D MoS₂ nanosheets for highly improved photothermal therapy of tumors in vitro and in vivo

C. Fu, L. Tan, X. Ren, Q. Wu, H. Shao, J. Ren, Y. Zhao and X. Meng, Chem. Commun., 2018, 54, 13989 DOI: 10.1039/C8CC08279K

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Chemical Communications