Jump to main content
Jump to site search

Issue 100, 2018
Previous Article Next Article

Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids

Author affiliations

Abstract

A radical cascade cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids with AgNO3 has been described. This reaction provides a novel route to directly access 3-acylbenzothiophenes from simple chemical feedstocks. In particular, the utility of the approach was demonstrated by its application to the synthesis of a polymerization inhibitor and a raloxifene precursor.

Graphical abstract: Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids

Back to tab navigation

Supplementary files

Article information


Submitted
27 Sep 2018
Accepted
26 Nov 2018
First published
26 Nov 2018

Chem. Commun., 2018,54, 14148-14151
Article type
Communication

Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with α-oxocarboxylic acids

W. Liu, Y. Hu, X. Hong, G. Li, X. Huang, W. Gao, M. Liu, Y. Xia, Y. Zhou and H. Wu, Chem. Commun., 2018, 54, 14148
DOI: 10.1039/C8CC07735E

Social activity

Search articles by author

Spotlight

Advertisements