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Issue 91, 2018
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Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

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Abstract

Ruthenium-catalysis enabled the C-5 selective C–H oxygenation of naphthoquinones, and also sets the stage for the site-selective introduction of a hydroxyl group into anthraquinones. A-ring modified naphthoquinoidal compounds represent an important class of bioactive quinones for which the present study encompasses the first C–H oxygenation strategy by weak O-coordination.

Graphical abstract: Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

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Article information


Submitted
18 Sep 2018
Accepted
16 Oct 2018
First published
16 Oct 2018

This article is Open Access

Chem. Commun., 2018,54, 12840-12843
Article type
Communication

Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents

G. G. Dias, T. Rogge, R. Kuniyil, C. Jacob, R. F. S. Menna-Barreto, E. N. da Silva Júnior and L. Ackermann, Chem. Commun., 2018, 54, 12840 DOI: 10.1039/C8CC07572G

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