Jump to main content
Jump to site search

Issue 85, 2018
Previous Article Next Article

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance

Author affiliations

Abstract

The chemical compound LY2874455 has the potential to overcome drug resistance driven by FGFR gatekeeper mutations. X-ray crystallographic studies provide the structural explanation for why this compound is effective against the FGFR gatekeeper mutations.

Graphical abstract: LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance

Back to tab navigation

Supplementary files

Article information


Submitted
18 Sep 2018
Accepted
28 Sep 2018
First published
29 Sep 2018

Chem. Commun., 2018,54, 12089-12092
Article type
Communication

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance

D. Wu, M. Guo, X. Min, S. Dai, M. Li, S. Tan, G. Li, X. Chen, Y. Ma, J. Li, L. Jiang, L. Qu, Z. Zhou, Z. Chen, L. Chen, G. Xu and Y. Chen, Chem. Commun., 2018, 54, 12089
DOI: 10.1039/C8CC07546H

Social activity

Search articles by author

Spotlight

Advertisements