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Issue 82, 2018
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Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe

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Abstract

We report senescence imaging with a fluorescence-quenched self-immolative sialoside probe (Sia-RQ) which gives a reactive quinone methide to allow in situ fluorescence labeling of sialidases upon desialylation. Dramatic upregulation of lysosome-associated sialidase was uncovered in cell senescence with Sia-RQ, suggesting the use of sialidase as a new biomarker for senescence.

Graphical abstract: Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe

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Publication details

The article was received on 29 Aug 2018, accepted on 20 Sep 2018 and first published on 20 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07024E
Citation: Chem. Commun., 2018,54, 11566-11569

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    Senescence-associated sialidase revealed by an activatable fluorescence-on labeling probe

    R. Zhu, S. Wang, Z. Xue, J. Han and S. Han, Chem. Commun., 2018, 54, 11566
    DOI: 10.1039/C8CC07024E

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