Jump to main content
Jump to site search

Issue 80, 2018
Previous Article Next Article

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Author affiliations

Abstract

Heterocycles based on piperidine and pyrrolidine are key moieties in natural products and pharmaceutically active molecules. A novel multi-enzymatic approach based on the combination of a lipase with an α,ω-diamine transaminase is reported, opening up the synthesis, isolation and characterisation of a broad range of 2-substituted N-heterocycle alkaloids.

Graphical abstract: Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Aug 2018, accepted on 17 Sep 2018 and first published on 17 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06759G
Citation: Chem. Commun., 2018,54, 11316-11319
  •   Request permissions

    Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

    J. L. Galman, I. Slabu, F. Parmeggiani and N. J. Turner, Chem. Commun., 2018, 54, 11316
    DOI: 10.1039/C8CC06759G

Search articles by author

Spotlight

Advertisements