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Issue 97, 2018
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Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs

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Abstract

Other than more widely used methods, the use of styrene maleic acid allows the direct extraction of membrane proteins from the lipid bilayer into SMALPs keeping it in its native lipid surrounding. Here we present the combined use of SMALPs and LILBID-MS, allowing determination of oligomeric states of membrane proteins of different functionality directly from the native nanodiscs.

Graphical abstract: Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs

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Supplementary files

Article information


Submitted
02 Aug 2018
Accepted
06 Sep 2018
First published
19 Nov 2018

This article is Open Access

Chem. Commun., 2018,54, 13702-13705
Article type
Communication

Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs

N. Hellwig, O. Peetz, Z. Ahdash, I. Tascón, P. J. Booth, V. Mikusevic, M. Diskowski, A. Politis, Y. Hellmich, I. Hänelt, E. Reading and N. Morgner, Chem. Commun., 2018, 54, 13702
DOI: 10.1039/C8CC06284F

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