Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(II) complexes

Yu Shen; Tao Shao; Bin Fang; Wei Du; Mingzhu Zhang; Jiejie Liu; Tianyan Liu; Xiaohe Tian; Qiong Zhang; Aidong Wang; Jiaxiang Yang; Jieying Wu; Yupeng Tian

doi:10.1039/C8CC06276E

Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes†

Yu Shen,

‡^a Tao Shao,

‡^a Bin Fang,^a Wei Du,^a Mingzhu Zhang,^a Jiejie Liu,^b Tianyan Liu,^b Xiaohe Tian,

*^bc Qiong Zhang,

*^a Aidong Wang,^d Jiaxiang Yang,

^a Jieying Wu^a and Yupeng Tian

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China
E-mail: zhangqiong.314@163.com, yptian@ahu.edu.cn

^b School of Life Science, Anhui University, Hefei 230601, P. R. China
E-mail: xiaohe.t@ahu.edu.cn

^c Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China

^d School of Chemistry and Chemical Engineering, Huangshan College, Huangshan 245041, P. R. China

Abstract

We present a thiophene-based terpyridine Zn(II) complex (namely LC) which could specifically target live cell mitochondria via binding with mitochondrial DNA (mtDNA). Due to its high biocompatibility, red emission and photo-stability, mtDNA distribution within mitochondrial cristae and inner matrix in living cells was successfully visualized using stimulated emission depletion (STED) nanoscopy with unprecedented resolution.

Chemical Communications

Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes†

Abstract

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Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(II) complexes

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