Issue 79, 2018

Rhodium(iii)-catalyzed C–H activation at the C4-position of indole: switchable hydroarylation and oxidative Heck-type reactions of maleimides

Abstract

A Rh(III)-catalyzed C–H activation of indole at the C4-position leading to novel and switchable functionalization has been reported by employing a weakly co-ordinating COCF3 group as a directing group. An additive plays an important role in switching the selectivity between 1,4-addition products and Heck-type products. An acid additive led to the formation of 1,4-addition products whereas a base additive promotes the formation of Heck-type products. Deuteration studies and control experiments were helpful to propose the mechanism.

Graphical abstract: Rhodium(iii)-catalyzed C–H activation at the C4-position of indole: switchable hydroarylation and oxidative Heck-type reactions of maleimides

Supplementary files

Article information

Article type
Communication
Submitted
01 Aug 2018
Accepted
06 Sep 2018
First published
06 Sep 2018

Chem. Commun., 2018,54, 11200-11203

Rhodium(III)-catalyzed C–H activation at the C4-position of indole: switchable hydroarylation and oxidative Heck-type reactions of maleimides

M. S. Sherikar, R. Kapanaiah, V. Lanke and K. R. Prabhu, Chem. Commun., 2018, 54, 11200 DOI: 10.1039/C8CC06264A

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