A new electrochemical aptasensor for sensitive assay of a protein based on the dual-signaling electrochemical ratiometric method and DNA walker strategy

Caixia Zhu; Mengyue Liu; Xiaoyu Li; Xiaohua Zhang; Jinhua Chen

doi:10.1039/C8CC05829F

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A new electrochemical aptasensor for sensitive assay of a protein based on the dual-signaling electrochemical ratiometric method and DNA walker strategy†

Caixia Zhu,^a Mengyue Liu,^a Xiaoyu Li,^a Xiaohua Zhang

^a and Jinhua Chen

*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P. R. China
E-mail: chenjinhua@hnu.edu.cn
Fax: +86-731-88821848
Tel: +86-731-88821848

Abstract

Herein, a new electrochemical aptamer-based biosensor for highly sensitive assay of thrombin has been developed based on the dual-signaling electrochemical ratiometric method and the DNA walker strategy, and shows a low detection limit of about 56 fM.

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Article information

DOI: https://doi.org/10.1039/C8CC05829F
Article type: Communication
Submitted: 18 Jul 2018
Accepted: 20 Aug 2018
First published: 21 Aug 2018

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Chem. Commun., 2018,54, 10359-10362

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A new electrochemical aptasensor for sensitive assay of a protein based on the dual-signaling electrochemical ratiometric method and DNA walker strategy

C. Zhu, M. Liu, X. Li, X. Zhang and J. Chen, Chem. Commun., 2018, 54, 10359 DOI: 10.1039/C8CC05829F

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Chemical Communications

A new electrochemical aptasensor for sensitive assay of a protein based on the dual-signaling electrochemical ratiometric method and DNA walker strategy†

Abstract

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A new electrochemical aptasensor for sensitive assay of a protein based on the dual-signaling electrochemical ratiometric method and DNA walker strategy

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