Issue 67, 2018
From the journal:

Chemical Communications

Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs†

Debmalya Bhunia, ORCID logo a   Krishnangsu Pradhan,a   Gaurav Das, ORCID logo ab   Subhajit Ghosh,a   Prasenjit Mondal ORCID logo ab  and  Surajit Ghosh ORCID logo *ab  

* Corresponding authors

a Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in

b Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4 Raja S. C. Mullick Road, Kolkata 700 032, India

Abstract

A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a MMP9 enzymatic site. Interestingly, it has a propensity to encapsulate and deliver the doxorubicin drug specifically to the cancer cell, induces superior apoptotic death, and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids.

Graphical abstract: Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C8CC05687K
Article type
Communication
Submitted
13 Jul 2018
Accepted
24 Jul 2018
First published
24 Jul 2018

Chem. Commun., 2018,54, 9309-9312

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Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs

D. Bhunia, K. Pradhan, G. Das, S. Ghosh, P. Mondal and S. Ghosh, Chem. Commun., 2018, 54, 9309 DOI: 10.1039/C8CC05687K

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