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Issue 79, 2018
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Rhodium(III)-catalyzed directed amidation of unactivated C(sp3)–H bonds to afford 1,2-amino alcohol derivatives

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Abstract

A rhodium-catalyzed directed C(sp3)–H amidation to afford 1,2-amino alcohol oxime derivatives has been developed with good yields and a broad substrate scope. In previous methods for this type of reaction, 1-arylethan-1-ol oxime analogues were challenging substrates owing to strong competition from C(sp2)–H bond activation. This Rh-catalyzed C–H activation method overcomes the limitation of competitive C(sp2)–H bond activation.

Graphical abstract: Rhodium(iii)-catalyzed directed amidation of unactivated C(sp3)–H bonds to afford 1,2-amino alcohol derivatives

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Publication details

The article was received on 12 Jul 2018, accepted on 09 Aug 2018 and first published on 15 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05637D
Citation: Chem. Commun., 2018,54, 11096-11099

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    Rhodium(III)-catalyzed directed amidation of unactivated C(sp3)–H bonds to afford 1,2-amino alcohol derivatives

    Y. Dong, J. Chen and H. Xu, Chem. Commun., 2018, 54, 11096
    DOI: 10.1039/C8CC05637D

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