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Issue 75, 2018
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A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

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Abstract

The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.

Graphical abstract: A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

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Publication details

The article was received on 01 Jul 2018, accepted on 24 Aug 2018 and first published on 27 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05281F
Chem. Commun., 2018,54, 10630-10633

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    A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

    L. A. Ho, J. L. Winogrodzki, A. W. Debowski, Z. Madden, D. J. Vocadlo, B. L. Mark and K. A. Stubbs, Chem. Commun., 2018, 54, 10630
    DOI: 10.1039/C8CC05281F

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