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Issue 80, 2018
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Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

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Abstract

The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.).

Graphical abstract: Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

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Submitted
20 Jun 2018
Accepted
07 Sep 2018
First published
11 Sep 2018

Chem. Commun., 2018,54, 11292-11295
Article type
Communication
Author version available

Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams via bronsted acid catalysis

Y. Tao and S. R. Gilbertson, Chem. Commun., 2018, 54, 11292
DOI: 10.1039/C8CC04946G

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