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Issue 63, 2018
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Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release

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Abstract

Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed. When the ester group in ADA2+ was hydrolyzed to a carboxyl group, the quaternary ammonium chain with a positive charge in ADA2+ converted to a “zwitterionic” structure, and the controlled binding and release of pDNA was realized.

Graphical abstract: Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release

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Publication details

The article was received on 14 Jun 2018, accepted on 09 Jul 2018 and first published on 10 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04783A
Citation: Chem. Commun., 2018,54, 8713-8716

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    Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release

    Y. Yang, X. Jia, Y. Zhang, N. Li and Y. Liu, Chem. Commun., 2018, 54, 8713
    DOI: 10.1039/C8CC04783A

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