Issue 62, 2018

A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

Abstract

Aminoacyladenylates (5′-aa-AMPs) are key intermediates in peptide synthesis. Here we report analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. Significantly, dipeptides were detected from the above reactions and their yields varied with different nucleosides through the formation of different aa-N-NMPs. This model provides both prebiotic peptides and the primordial version of the genetic code through reactions that occurred under potentially prebiotic conditions.

Graphical abstract: A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

Supplementary files

Article information

Article type
Communication
Submitted
14 Jun 2018
Accepted
06 Jul 2018
First published
07 Jul 2018

Chem. Commun., 2018,54, 8598-8601

A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

J. Ying, S. Fu, X. Li, L. Feng, P. Xu, Y. Liu, X. Gao and Y. Zhao, Chem. Commun., 2018, 54, 8598 DOI: 10.1039/C8CC04767G

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