Fluorine-18: an untapped resource in inorganic chemistry

Cassis Varlow; Daniel Szames; Kenneth Dahl; Vadim Bernard-Gauthier; Neil Vasdev

doi:10.1039/C8CC04751K

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Fluorine-18: an untapped resource in inorganic chemistry

Cassis Varlow,†^ab Daniel Szames,†^ab Kenneth Dahl,^ac Vadim Bernard-Gauthier^ac and Neil Vasdev

*^ac

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* Corresponding authors

^a Azrieli Centre for Neuro-Radiochemistry, Research Imaging Centre, Centre for Addiction and Mental Health, 250 College St. Toronto, ON, Canada
E-mail: neil.vasdev@utoronto.ca
Tel: +1-416-535-8501 ext. 30988

^b Department of Chemistry and Chemical Biology, McMaster University, 1280 Main St. W., Hamilton, ON, Canada

^c Department of Psychiatry, University of Toronto, 250 College St. Toronto, ON, Canada

Abstract

Advances in the field of fluorine chemistry have been applied extensively to the syntheses of ¹⁸F-labelled organic compounds and radiopharmaceuticals. However, ¹⁸F has sparely been used as a tool to explore inorganic chemistry and can be viewed as a research area worthy of further development. This review highlights the application of ¹⁸F in development of inorganic fluorinating agents, mechanistic studies and imaging tools.

This article is part of the themed collection: Fluorine Chemistry

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Article information

DOI: https://doi.org/10.1039/C8CC04751K
Article type: Highlight
Submitted: 13 Jun 2018
Accepted: 28 Aug 2018
First published: 29 Aug 2018

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Chem. Commun., 2018,54, 11835-11842

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Fluorine-18: an untapped resource in inorganic chemistry

C. Varlow, D. Szames, K. Dahl, V. Bernard-Gauthier and N. Vasdev, Chem. Commun., 2018, 54, 11835 DOI: 10.1039/C8CC04751K

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Fluorine-18: an untapped resource in inorganic chemistry

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Fluorine-18: an untapped resource in inorganic chemistry

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