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Issue 73, 2018
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Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates

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Abstract

The dynamic interactions of an individual matrix metalloproteinase-1 were imaged and monitored in the presence of either triple-helical or non-triple-helical, partially structured collagen-mimic substrates. The enzyme exhibited ten-fold increased catalytic turnover rates with the structurally modified substrate by skipping the triple-helix unwinding step during the catalytic pathway.

Graphical abstract: Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates

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Publication details

The article was received on 09 Jun 2018, accepted on 25 Jul 2018 and first published on 25 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04601H
Citation: Chem. Commun., 2018,54, 10248-10251

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    Real-time tracking of single-molecule collagenase on native collagen and partially structured collagen-mimic substrates

    J. Froberg, W. Choi, A. Sedigh, T. Anajafi, J. Farmakes, Z. Yang, S. Mallik, D. K. Srivastava and Y. Choi, Chem. Commun., 2018, 54, 10248
    DOI: 10.1039/C8CC04601H

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