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Issue 68, 2018
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Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

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Abstract

A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.

Graphical abstract: Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

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Supplementary files

Article information


Submitted
20 May 2018
Accepted
02 Jul 2018
First published
03 Jul 2018

Chem. Commun., 2018,54, 9394-9397
Article type
Communication

Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

Y. Tian, Y. Huang, P. Gao and T. Chen, Chem. Commun., 2018, 54, 9394
DOI: 10.1039/C8CC04021D

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