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Issue 68, 2018
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Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

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Abstract

In this study ion mobility-mass spectrometry (IM-MS) is used to distinguish chiral diastereomers of the nonapeptides desmopressin and vasopressin. The differences in gas phase cross sectional area (ca. 2%) were sufficient to directly resolve the enantiomers present in a binary mixture. Results from computational modeling indicate that chiral recognition by IM-MS for nonapeptides is possible due to their diastereomer-specific conformations adopted in the gas-phase, namely a compact ring-tail conformer specific to the L-diastereomer forms.

Graphical abstract: Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

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Publication details

The article was received on 10 May 2018, accepted on 24 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03790F
Citation: Chem. Commun., 2018,54, 9398-9401
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    Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

    S. T. Phillips, J. N. Dodds, B. M. Ellis, J. C. May and J. A. McLean, Chem. Commun., 2018, 54, 9398
    DOI: 10.1039/C8CC03790F

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