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Issue 68, 2018
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Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

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Abstract

In this study ion mobility-mass spectrometry (IM-MS) is used to distinguish chiral diastereomers of the nonapeptides desmopressin and vasopressin. The differences in gas phase cross sectional area (ca. 2%) were sufficient to directly resolve the enantiomers present in a binary mixture. Results from computational modeling indicate that chiral recognition by IM-MS for nonapeptides is possible due to their diastereomer-specific conformations adopted in the gas-phase, namely a compact ring-tail conformer specific to the L-diastereomer forms.

Graphical abstract: Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

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Supplementary files

Article information


Submitted
10 May 2018
Accepted
24 Jul 2018
First published
31 Jul 2018

Chem. Commun., 2018,54, 9398-9401
Article type
Communication

Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

S. T. Phillips, J. N. Dodds, B. M. Ellis, J. C. May and J. A. McLean, Chem. Commun., 2018, 54, 9398
DOI: 10.1039/C8CC03790F

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