Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

Soumik Dinda; Saheli Sarkar; Prasanta Kumar Das

doi:10.1039/C8CC03599G

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Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles†

Soumik Dinda,^a Saheli Sarkar^a and Prasanta Kumar Das

*^a

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* Corresponding authors

^a Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata – 700 032, India
E-mail: bcpkd@iacs.res.in
Fax: +91-33-24732805

Abstract

Herein, we demonstrate glucose oxidase (GOx) mediated targeted cancer-starving therapy by self-assembled vesicle of trimesic acid based biotinylated amphiphile (TMB). The TMB vesicles entrapped GOx and selectively killed cancer cells (HeLa, B16F10), with ∼6-fold higher efficiency compared to non-cancer cells (CHO, NIH3T3), by blocking the energy supply to tumors through the oxidation of intracellular glucose.

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DOI: https://doi.org/10.1039/C8CC03599G
Article type: Communication
Submitted: 04 May 2018
Accepted: 02 Aug 2018
First published: 03 Aug 2018

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Chem. Commun., 2018,54, 9929-9932

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Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

S. Dinda, S. Sarkar and P. K. Das, Chem. Commun., 2018, 54, 9929 DOI: 10.1039/C8CC03599G

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Chemical Communications

Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles†

Abstract

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Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles

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