Issue 55, 2018
From the journal:

Chemical Communications

Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors†

Xiaoyuan Wu,‡ab   Bingyuan Guo,‡b   Yingying Sheng,c   Yun Zhang,c   Jin Wang,a   Shuchuan Peng,*a   Lei Liu ORCID logo *b  and  Hai-Chen Wu ORCID logo *c  

* Corresponding authors

a School of Resource and Environmental Engineering, Hefei University of Technology, Hefei 230009, China

b Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Multidisciplinary Center, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
E-mail: leiliu@ihep.ac.cn

c Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: haichenwu@iccas.ac.cn

Abstract

Herein, we develop a new nanopore sensing strategy for the selective detection of microRNAs and single nucleotide variants (SNVs) based on triplex molecular beacon sensors. This sensing system shows very high specificity in discriminating microRNA SNVs and can be applied for the simultaneous detection of several microRNAs of the same family in a mixture.

Graphical abstract: Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors

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Article information

DOI
https://doi.org/10.1039/C8CC03574A
Article type
Communication
Submitted
03 May 2018
Accepted
14 Jun 2018
First published
15 Jun 2018

Chem. Commun., 2018,54, 7673-7676

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Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors

X. Wu, B. Guo, Y. Sheng, Y. Zhang, J. Wang, S. Peng, L. Liu and H. Wu, Chem. Commun., 2018, 54, 7673 DOI: 10.1039/C8CC03574A

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