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Issue 43, 2018
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hIAPP forms toxic oligomers in plasma

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In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

Graphical abstract: hIAPP forms toxic oligomers in plasma

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17 Apr 2018
30 Apr 2018
First published
30 Apr 2018

Chem. Commun., 2018,54, 5426-5429
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hIAPP forms toxic oligomers in plasma

D. C. Rodriguez Camargo, D. Garg, K. Buday, A. Franko, A. Rodriguez Camargo, F. Schmidt, S. J. Cox, S. Suladze, M. Haslbeck, Y. G. Mideksa, G. Gemmecker, M. Aichler, G. Mettenleiter, M. Schulz, A. K. Walch, M. Hrabě de Angelis, M. J. Feige, C. A. Sierra, M. Conrad, K. Tripsianes, A. Ramamoorthy and B. Reif, Chem. Commun., 2018, 54, 5426
DOI: 10.1039/C8CC03097A

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