Jump to main content
Jump to site search

Issue 43, 2018
Previous Article Next Article

hIAPP forms toxic oligomers in plasma

Author affiliations

Abstract

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in β-sheet rich oligomers with increased β-cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

Graphical abstract: hIAPP forms toxic oligomers in plasma

Back to tab navigation

Supplementary files

Article information


Submitted
17 Apr 2018
Accepted
30 Apr 2018
First published
30 Apr 2018

Chem. Commun., 2018,54, 5426-5429
Article type
Communication

hIAPP forms toxic oligomers in plasma

D. C. Rodriguez Camargo, D. Garg, K. Buday, A. Franko, A. Rodriguez Camargo, F. Schmidt, S. J. Cox, S. Suladze, M. Haslbeck, Y. G. Mideksa, G. Gemmecker, M. Aichler, G. Mettenleiter, M. Schulz, A. K. Walch, M. Hrabě de Angelis, M. J. Feige, C. A. Sierra, M. Conrad, K. Tripsianes, A. Ramamoorthy and B. Reif, Chem. Commun., 2018, 54, 5426
DOI: 10.1039/C8CC03097A

Social activity

Search articles by author

Spotlight

Advertisements