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Issue 50, 2018
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Bead-based screening in chemical biology and drug discovery

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High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.

Graphical abstract: Bead-based screening in chemical biology and drug discovery

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Publication details

The article was received on 27 Mar 2018, accepted on 30 May 2018 and first published on 30 May 2018

Article type: Feature Article
DOI: 10.1039/C8CC02486C
Citation: Chem. Commun., 2018,54, 6759-6771

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    Bead-based screening in chemical biology and drug discovery

    V. V. Komnatnyy, T. E. Nielsen and K. Qvortrup, Chem. Commun., 2018, 54, 6759
    DOI: 10.1039/C8CC02486C

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