Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

Kristina Roth Stefaniak; Charity C. Epley; Joshua J. Novak; Margaret L. McAndrew; Hannah D. Cornell; Jie Zhu; Dylan K. McDaniel; Jennifer L. Davis; Irving C. Allen; Amanda J. Morris; Tijana Z. Grove

doi:10.1039/C8CC01601A

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle†

Kristina Roth Stefaniak,

‡§^a Charity C. Epley,‡^a Joshua J. Novak,

^a Margaret L. McAndrew,^a Hannah D. Cornell,

^a Jie Zhu,^a Dylan K. McDaniel,^b Jennifer L. Davis,

^b Irving C. Allen,

^b Amanda J. Morris

*^a and Tijana Z. Grove

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24060, USA
E-mail: tijana.grove@vt.edu, ajmorris@vt.edu

^b Department of Biomedical Sciences and Pathobiology, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA

Abstract

A nano metal–organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

Chemical Communications

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle†

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