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Issue 63, 2018

A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

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Abstract

This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.

Graphical abstract: A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

Supplementary files

Article information


Submitted
24 Feb 2018
Accepted
25 Jun 2018
First published
25 Jun 2018

Chem. Commun., 2018,54, 8693-8696
Article type
Communication
Author version available

A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice

A. Ogura, S. Urano, T. Tahara, S. Nozaki, R. Sibgatullina, K. Vong, T. Suzuki, N. Dohmae, A. Kurbangalieva, Y. Watanabe and K. Tanaka, Chem. Commun., 2018, 54, 8693 DOI: 10.1039/C8CC01544A

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